山部茜子先生の論文が、Bio-Medical Materials and Engineering誌(Journal Citation Reports Impact Factor 2019 = 1.243)にpublishされました。

Biomed Mater Eng 2021 Mar 3
doi: 10.3233/BME-201163. Online ahead of print.

Development of biliary stent applying the antibacterial activity of silver: A literature review

Akane Yamabe, Atsushi Irisawa, Yasuhito Kunogi, Ken Kashima, Kazunori Nagashima, Takahito Minaguchi, Akira Yamamiya, Naoya Izawa, Yoichi Takimoto, Koki Hoshi, Risa Nonaka, Michiaki Masuda, Keiichi Tominaga, Kenichi Goda, Makoto Iijima

Affiliations expand
PMID: 33720871 DOI: 10.3233/BME-201163

Abstract
Background: Endoscopic transpapillary stenting is commonly performed in patients with obstructive jaundice caused by a biliary stricture. Although the plastic stent (PS) is widely used for biliary drainage because of the low-cost and easy procedure, patency is short after placement in the bile duct because of the small diameter. Dysfunction of PS is primarily caused by biliary sludge that forms as a result of bacterial adhesion and subsequent biofilm formation on the inner surface of the stent. It is well known that silver ions have excellent antibacterial activity against a wide range of microorganisms.

Objective: This review provides an overview and perspective of the significance of silver-coated biliary stents.

Methods: We collected literature regarding silver-coated biliary stents, and reviewed the current research/development status and discussed their possible usefulness.

Results: To date, several in vivo/vitro studies evaluated the patency of silver-blended or silver-coated biliary stents. These studies suggested that the silver coating on a PS was likely to prolong the patency period.

Conclusion: The development of biliary stents using silver is expected to prolong stent patency and prevent frequent stent replacement.

Keywords: Biliary stent; biliary obstruction; biofilm; silver-coating.

https://pubmed.ncbi.nlm.nih.gov/33720871/