福士耕先生の論文が、World journal of gastroenterology誌(Journal Citation Reports Impact Factor 2020 = 5.742)にpublishされました。

World J Gastroenterol. 2022 Feb 7;28(5):594-601. doi: 10.3748/wjg.v28.i5.594.

Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease: A case report

Koh Fukushi, Kenichi Goda, Hitoshi Kino, Masayuki Kondo, Mimari Kanazawa, Ken Kashima, Akira Kanamori, Keiichiro Abe, Tsunehiro Suzuki, Keiichi Tominaga, Hidetsugu Yamagishi, Atsushi Irisawa

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PMID: 35316958 PMCID: PMC8905015 DOI:10.3748/wjg.v28.i5.594

Abstruct
Background: Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori (H. pylori) infection and an elevated risk of carcinogenesis. Cases of early-stage gastric cancer developed in H. pylori-negative Ménétrier’s disease are extremely rare. We report a case of early gastric cancer in H. pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection (ESD).

Case summary: A 60-year-old woman was referred to our hospital after her medical examination detected anemia. Contrast-enhanced upper gastrointestinal (UGI) radiography revealed translucency of the nodule-aggregating surface with giant rugae. Blood tests showed hypoproteinemia and were negative for serum H. pylori immunoglobulin G antibodies. The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach. UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body, suggesting early-stage gastric cancer due to Ménétrier’s disease. En bloc resection with ESD was performed for diagnosis and treatment. Histology of ESD showed well-differentiated tubular adenocarcinoma. The cancer was confined to the mucosa, and complete curative resection was achieved. Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas, histologically corresponding to Ménétrier’s disease. Three years after ESD, gastric cancer had not recurred, and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.

Conclusion: Complete curative resection was achieved through ESD in a patient with early-stage gastric cancer and H. pylori-negative Ménétrier’s disease.

Keywords: Case report; Endoscopic resection; Endoscopic submucosal dissection; Gastric cancer; Helicobacter pylori; Ménétrier’s disease.

https://pubmed.ncbi.nlm.nih.gov/35316958/