鈴木統裕先生の論文が、Journal of Clinical Medicine誌(Journal Citation Reports Impact Factor 2022 = 3.9)にpublishされました。

J Clin Med. 2024 Mar 10;13(6):1587. doi: 10.3390/jcm13061587.

Risk Factors for Developing Metachronous Superficial Gastric Epithelial Neoplasms after Endoscopic Submucosal Dissection

Tsunehiro Suzuki, Kenichi Goda, Manabu Ishikawa, Shintaro Yamaguchi, Tomonori Yoshinaga, Masayuki Kondo, Mimari Kanazawa, Yasuhito Kunogi, Takanao Tanaka, Akira Kanamori, Keiichiro Abe, Akira Yamamiya, Takeshi Sugaya, Keiichi Tominaga, Hidetsugu Yamagishi, Hironori Masuyama, Atsushi Irisawa

Affiliations expand
PMID: 38541812 PMCID: PMC10970914 DOI: 10.3390/jcm13061587

Abstract
Background: Although endoscopic submucosal dissection (ESD) provides a high rate of curative resection, the remaining gastric mucosa after ESD is at risk for metachronous superficial gastric epithelial neoplasms (MSGENs). It leaves room for risk factors for developing MSGENs after ESD. This study aimed to identify clinicopathological risk factors for the occurrence of MSGENs, and to evaluate the association of Helicobacter pylori (H. pylori) with the MSGENs. Methods: We conducted a retrospective cohort study including 369 patients with 382 lesions that underwent ESD for adenoma/early gastric cancer. Results: Twenty-seven MSGENs occurred. The subjects were divided into MSGEN and not-MSGEN groups. There was a significantly higher frequency of histological intestinal metaplasia (HIM) and initial neoplasm location in the upper or middle parts (INUM) in the MSGEN group. The HIM and INUM groups had a significantly higher cumulative incidence of MSGENs. We compared 27 patients from the MSGEN group and 27 patients from the not-MSGEN group that were matched to the MSGEN group for variables including HIM and INUM. There was a significantly higher frequency of the spontaneous disappearance of H. pylori in the MSGEN group. Conclusions: HIM, INUM, and the spontaneous disappearance of H. pylori may be clinicopathological risk factors for developing MSGENs after ESD.

Keywords: Helicobacter pylori; cumulative incidence; early gastric cancer; endoscopic resection; endoscopic submucosal dissection; gastric adenoma; intestinal metaplasia; metachronous cancer; spontaneous disappearance; stomach.

https://pubmed.ncbi.nlm.nih.gov/38541812/